calc_krbc2pu {httk} | R Documentation |
Back-calculates the Red Blood Cell to Unbound Plasma Partition Coefficient
Description
Given an observed ratio of chemical concentration in blood to plasma, this function calculates a Red Blood Cell to unbound plasma (Krbc2pu) partition coefficient that would be consistent with that observation.
Usage
calc_krbc2pu(
Rb2p,
Funbound.plasma,
hematocrit = NULL,
default.to.human = FALSE,
species = "Human",
suppress.messages = TRUE
)
Arguments
Rb2p |
The chemical blood:plasma concentration ratop |
Funbound.plasma |
The free fraction of chemical in the presence of plasma protein Rblood2plasma. |
hematocrit |
Overwrites default hematocrit value in calculating Rblood2plasma. |
default.to.human |
Substitutes missing animal values with human values if true. |
species |
Species desired (either "Rat", "Rabbit", "Dog", "Mouse", or default "Human"). |
suppress.messages |
Determine whether to display certain usage feedback. |
Value
The red blood cell to unbound chemical in plasma partition coefficient.
Author(s)
John Wambaugh and Robert Pearce
References
Pearce RG, Setzer RW, Davis JL, Wambaugh JF (2017). “Evaluation and calibration of high-throughput predictions of chemical distribution to tissues.” Journal of pharmacokinetics and pharmacodynamics, 44, 549–565. doi:10.1007/s10928-017-9548-7.
Ruark CD, Hack CE, Robinson PJ, Mahle DA, Gearhart JM (2014). “Predicting passive and active tissue: plasma partition coefficients: interindividual and interspecies variability.” Journal of pharmaceutical sciences, 103(7), 2189–2198. doi:10.1002/jps.24011.