Remission {R4HCR} | R Documentation |
Effect of 6-mercaptopurine (6-MP) on the Duration of Remission in Acute Leukemia.
Description
Duration of remission for acute leukemia patients on active treatment or placebo.
Usage
Remission
Format
A data frame with 42 observations on the following 5 variables.
sex
Sex of the patient (
0
= male,1
= female).wbc
log white-blood cell count (WBC).
time
Time to event, where the event is either relapse or loss to follow up.
event
Indicator of event type, either
Relapse
orCensored
.grp
Treatment group (
6-MP
= allocated to active treament, orPlacebo
).
Details
In this study, patients in remission were randomly assigned to maintenance therapy with 6-MP, an active antileukemic compound 6-MP, or a placebo. White blood cell count was also recorded as this was considered a prognostic indicator of survival for leukemia patients, with the higher values being associated with a worse prognosis.
Source
Kleinbaum, D.G. and Klein, M., 1996. Survival Analysis: A Self-Learning Text. Springer.
References
Acute Leukemia Group B, Freireich, E.J., Gehan, E., Frei III, E.M.I.L., Schroeder, L.R., Wolman, I.J., Anbari, R., Burgert, E.O., Mills, S.D., Pinkel, D. and Selawry, O.S., 1963. The effect of 6-mercaptopurine on the duration of steroid-induced remissions in acute leukemia: A model for evaluation of other potentially useful therapy. Blood, 21(6), pp.699-716.
Examples
data(Remission, package = "R4HCR")
# Number of events/censored by group
aggregate(event ~ grp,
data = Remission,
FUN = table)
# median survival times, ignoring the censoring.
aggregate(time ~ grp,
data = Remission,
FUN = median)