opchars.tite {stoppingrule} | R Documentation |
Operating Characteristics Function (TITE Method)
Description
Internal workhorse function to calculate operating characteristics for a given stopping rule and toxicity probability
Usage
opchars.tite(rule, p, tau, MC, A, family, s)
Arguments
rule |
A |
p |
Vector of cumulative incidence probabilities at time |
tau |
Length of observation period |
MC |
Number of Monte Carlo replicated datasets to simulate |
A |
Length of accrual period |
family |
Event time distribution, choices including Weibull distribution ('weibull') and power family ('power') |
s |
Shape parameter for Weibull distribution or power parameter for power family |
Value
A list containing the toxicity probability p
, and the corresponding rejection probability and expected number of events. If tau
and A
are also specified, the expected number of enrolled patients and the expected calendar time at the point of stopping/study end are also included.