opchars.tite {stoppingrule}R Documentation

Operating Characteristics Function (TITE Method)

Description

Internal workhorse function to calculate operating characteristics for a given stopping rule and toxicity probability

Usage

opchars.tite(rule, p, tau, MC, A, family, s)

Arguments

rule

A rule.tite object with the safety stopping rule for evaluation

p

Vector of cumulative incidence probabilities at time tau for all causes (length 1 for survival, 2 for competing risks)

tau

Length of observation period

MC

Number of Monte Carlo replicated datasets to simulate

A

Length of accrual period

family

Event time distribution, choices including Weibull distribution ('weibull') and power family ('power')

s

Shape parameter for Weibull distribution or power parameter for power family

Value

A list containing the toxicity probability p, and the corresponding rejection probability and expected number of events. If tau and A are also specified, the expected number of enrolled patients and the expected calendar time at the point of stopping/study end are also included.


[Package stoppingrule version 0.6 Index]