antidepressants {netdose} | R Documentation |
Antidepressants Dataset for Dose-Response Network Meta-Analysis
Description
This dataset is a synthesis of randomized controlled studies investigating the effects of antidepressant interventions for unipolar major depressive disorder.
Usage
antidepressants
Format
A data frame with the following columns:
drug | Character vector indicating the name of the antidepressant agent. |
r | Integer vector for the number of participants who responded to treatment. |
n | Integer vector for the total number of participants in the study arm. |
dose | Numeric vector specifying the dose level of the antidepressant agent. |
studyid | Character vector with unique study identifiers. |
Details
The dataset includes data on several antidepressant agents and their observed effects across multiple clinical randomized controlled trials. The primary outcome is the response rate, defined as the proportion of patients achieving at least a 50
The dataset is structured in an arm-level format and includes the following variables:
-
drug
: Name of the antidepressant agent. -
r
: Number of participants who responded to treatment. -
n
: Total number of participants in the study arm. -
dose
: Dose level of the antidepressant agent. -
studyid
: Unique study identifier.
This dataset is intended for use in dose-response network meta-analysis to explore the effects of the several agents across various doses.
Source
The dataset is a subset of data derived from: Cipriani A et al. Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis. The Lancet. 2018;391:1357–1366.
Examples
data(antidepressants)
# Summarize the dataset
summary(antidepressants)