anesthesia {netdose} | R Documentation |
Anesthesia Dataset for Dose-Response Network Meta-Analysis
Description
This dataset is a synthesis of randomized controlled studies investigating the effects of different agents for preventing vomiting within 24 h postoperatively in adults after general anaesthesia. Multicomponent interventions have been excluded from this subset to focus on single-agent interventions and their dose-response relationships.
Usage
anesthesia
Format
A data frame with the following columns:
agent1 | Character vector indicating the name of the agent in arm 1. |
agent2 | Character vector indicating the name of the agent in arm 2. |
agent3 | Character vector indicating the name of the agent in arm 3. |
agent4 | Character vector indicating the name of the agent in arm 4. |
agent5 | Character vector indicating the name of the agent in arm 5. |
event1 | Integer vector for the number of participants who experienced vomiting in arm 1. |
event2 | Integer vector for the number of participants who experienced vomiting in arm 2. |
event3 | Integer vector for the number of participants who experienced vomiting in arm 3. |
event4 | Integer vector for the number of participants who experienced vomiting in arm 4. |
event5 | Integer vector for the number of participants who experienced vomiting in arm 5. |
n1 | Integer vector for the total number of participants in study arm 1. |
n2 | Integer vector for the total number of participants in study arm 2. |
n3 | Integer vector for the total number of participants in study arm 3. |
n4 | Integer vector for the total number of participants in study arm 4. |
n5 | Integer vector for the total number of participants in study arm 5. |
dose1 | Numeric vector specifying the dose level in arm 1. |
dose2 | Numeric vector specifying the dose level in arm 2. |
dose3 | Numeric vector specifying the dose level in arm 3. |
dose4 | Numeric vector specifying the dose level in arm 4. |
dose5 | Numeric vector specifying the dose level in arm 5. |
studyid | Character vector with unique study identifiers. |
Details
The dataset includes data on several agents for preventing vomiting and their observed effects across multiple clinical randomized controlled trials. The outcome is the occurrence of vomiting within 24 hours after surgery. By excluding multicomponent interventions, this subset allows for a more precise evaluation of single-agent dose-response relationships.
The dataset is structured in a contrast-based format and includes the following variables:
-
agent1
,agent2
,agent3
,agent4
,agent5
: Names of the agents used in each study arm. -
event1
,event2
,event3
,event4
,event5
: Number of participants who experienced vomiting within 24 hours postoperatively in each study arm. -
n1
,n2
,n3
,n4
,n5
: Total number of participants in each study arm. -
dose1
,dose2
,dose3
,dose4
,dose5
: Dose levels of the agents in each study arm. -
studyid
: Unique identifier for the study.
This dataset is intended for use in dose-response network meta-analysis to explore the effects of single agents across various doses.
Source
The dataset is a subset of data derived from: Weibel S, Rücker G, Eberhart LHJ, et al. Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: a network meta-analysis. Cochrane Database of Systematic Reviews. 2020;10(10):CD012859. Weibel S, Schaefer MS, Raj D, et al. Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: an abridged Cochrane network meta-analysis. Anaesthesia. 2021;76:962-973.
Examples
data(anesthesia)
# Summarize the dataset
summary(anesthesia)