calc_total_clearance {httk} | R Documentation |
Calculate the total plasma clearance.
Description
This function calculates the total clearance rate for a one compartment model for plasma where clearance is entirely due to metablism by the liver and glomerular filtration in the kidneys, identical to clearance of three compartment steady state model.
Usage
calc_total_clearance(
chem.cas = NULL,
chem.name = NULL,
dtxsid = NULL,
parameters = NULL,
model = "3compartmentss",
suppress.messages = FALSE,
species = "Human",
...
)
Arguments
chem.cas |
Either the chemical name, CAS number, or the parameters must be specified. |
chem.name |
Either the chemical name, CAS number, or the parameters must be specified. |
dtxsid |
EPA's 'DSSTox Structure ID (https://comptox.epa.gov/dashboard) the chemical must be identified by either CAS, name, or DTXSIDs |
parameters |
Chemical parameters from parameterize_steadystate function, overrides chem.name and chem.cas. |
model |
The model used to calculate total clearance (defaults to "3compartmentss") |
suppress.messages |
Whether or not the output message is suppressed. |
species |
Species desired (either "Rat", "Rabbit", "Dog", "Mouse", or default "Human"). |
... |
Additional parameters passed to parameterize function if parameters is NULL. |
Value
Total Clearance |
Units of L/h/kg BW. |
Author(s)
John Wambaugh
Examples
calc_total_clearance(chem.name="Ibuprofen")