concentration_data_Linakis2020 {httk}R Documentation

Concentration data involved in Linakis 2020 vignette analysis.

Description

These rat and human TK concentration vs. time (CvT) data are drawn from the CvTdb (Sayre et el., 2020). Concentrations have all been converted to the units of uM. All data are from inhalation studies.

Usage

concentration_data_Linakis2020

Format

A data.frame containing 2142 rows and 16 columns.

Details

Abbreviations used for sampling matrix: BL : blood EEB : end-exhaled breath MEB : mixed exhaled breath VBL : venous blood ABL : arterial blood EB : unspecified exhaled breath sample (assumed to be EEB) PL: plasma +W with work/exercise

Column Name Description
PREFERRED_NAME Substance preferred name
DTXSID Identifier for CompTox Chemical Dashboard
CASRN Chemical abstracts service registration number
AVERAGE_MASS Substance molecular weight g/mol
DOSE DOSE_U Inhalation exposure concentration in parts per million
EXP_LENGTH Duration of inhalation exposur
TIME Measurment time
TIME_U Time units for all times reported
CONC_SPECIES Species for study
SAMPLING_MATRIX Matrix analyzed
SOURCE_CVT Data source identifier within CvTdb
ORIG_CONC_U Original reported units for concentration
CONCENTRATION Analyte concentration in uM units

Author(s)

Matt Linakis

Source

Matt Linakis

References

Linakis MW, Sayre RR, Pearce RG, Sfeir MA, Sipes NS, Pangburn HA, Gearhart JM, Wambaugh JF (2020). “Development and evaluation of a high-throughput inhalation model for organic chemicals.” Journal of exposure science & environmental epidemiology, 30(5), 866–877. doi:10.1038/s41370-020-0238-y. Sayre RR, Wambaugh JF, Grulke CM (2020). “Database of pharmacokinetic time-series data and parameters for 144 environmental chemicals.” Scientific data, 7(1), 122. doi:10.1038/s41597-020-0455-1.


[Package httk version 2.7.0 Index]