grantham-package {grantham} | R Documentation |
grantham: Calculate the Grantham Distance
Description
A minimal set of routines to calculate the Grantham distance doi:10.1126/science.185.4154.862. The Grantham distance attempts to provide a proxy for the evolutionary distance between two amino acids based on three key chemical properties: composition, polarity and molecular volume. In turn, evolutionary distance is used as a proxy for the impact of missense mutations. The higher the distance, the more deleterious the substitution is expected to be.
Author(s)
Maintainer: Ramiro Magno rmagno@pattern.institute (ORCID)
Authors:
Isabel Duarte iduarte@pattern.institute (ORCID)
Ana-Teresa Maia maia.anateresa@gmail.com (ORCID)
Other contributors:
University of Algarve [funder]
CINTESIS [funder]
Pattern Institute (04jrgd746) [copyright holder, funder]
See Also
Useful links:
Report bugs at https://github.com/patterninstitute/grantham/issues