dtl_get_alpha_s {dtlcor} | R Documentation |
Significance level given a fixed correlation coefficient for the final stage under drop-the-losers (DTL) design
Description
Get significant level alpha_s based on a pre-specified FWER alpha given a fixed correlation coefficient for the final stage (reverse calculation of dtl_tier_the())
Usage
dtl_get_alpha_s(n, t, rho, q, alpha, delta)
Arguments
n |
Sample size per arm at DTL look |
t |
A vector of information fraction of final stage |
rho |
Fixed correlation coefficient |
q |
Response rate under the null |
alpha |
A pre-specified FWER |
delta |
Least difference to decide superiority of high dose |
Value
Significance level alpha_s for the final stage
Examples
# Without interim analysis
dtl_get_alpha_s(n = 80, t = 1, rho = 0.4, q = 0.3, alpha = 0.025, delta = 0.05)
[Package dtlcor version 0.1.0 Index]