EB {BuyseTest} | R Documentation |
Rare disease trial
Description
16 pediatric subjects suffering from a aare skin disease (epidermolysis bullosa simplex) treated with placebo or diacerin cream in a longitudinal cross-over trial (14 paired).
-
Id
: study participant. -
Time
: end of the 4 weeks treatment period (t4) or 12 weeks after treatment ended (t12) -
treatment
: treatment arm: diacerin cream (V) or placebo (P). -
StdDiffCount
: blister uncertainty -
Bin
: indicator of 40 -
DiffQoL
: Change in quality of life since baseline. -
period
: same as time but coded as numeric: 1 for t4 and 2 for t12
Usage
data(CHARM, package = "BuyseTest")
Format
An object of class data.frame
with 30 rows and 7 columns.
References
Wally et al. "Diacerein orphan drug development for epidermolysis bullosa simplex: A phase 2/3 randomized, placebo-controlled, double-blind clinical trial". Journal of American Academy of Dermatology (2018) 78(5):892-901. https://doi.org/10.1016/j.jaad.2018.01.019.