thyroid.ac50s {httk} | R Documentation |
ToxCast thyroid-related bioactivity data
Description
Truong et al. 2025 uses ToxCast data for 4 thyroid-related assay endpoints concerning inhibition of deiodinases ("DIO1", "DIO2", "DIO3", and "IYD") and identified 120 priority chemicals with activity for at least one deiodinase. These 120 chemicals were curated after assessment for target selectivity and assay interference.
Usage
thyroid.ac50s
Format
data.table and data.frame
Details
The AC50s (in uM) for each of the 120 chemicals were retrieved from ToxCast invitrodb v3.5 and are used in the "Full Human Gestational IVIVE" vignette.
References
Truong KT, Wambaugh JF, Kapraun DF, Davidson-Fritz SE, Eytcheson S, Judson RS, Paul Friedman K (2025). “Interpretation of thyroid-relevant bioactivity data for comparison to in vivo exposures: A prioritization approach for putative chemical inhibitors of in vitro deiodinase activity.” Toxicology. doi:10.1016/j.tox.2025.154157.