pksim.pcs {httk} | R Documentation |
Partition Coefficients from PK-Sim
Description
Dallmann et al. (2018) made use of PK-Sim to predict chemical- and tissue- specific partition coefficients. The methods include both the default PK-Sim approach and PK-Sim Standard and Rodgers & Rowland (2006).
Usage
pksim.pcs
Format
data.frame
Source
Kapraun DF, Sfeir M, Pearce RG, Davidson-Fritz SE, Lumen A, Dallmann A, Judson RS, Wambaugh JF (2022). “Evaluation of a rapid, generic human gestational dose model.” Reproductive Toxicology, 113, 172–188. doi:10.1016/j.reprotox.2022.09.004.
References
Dallmann A, Ince I, Coboeken K, Eissing T, Hempel G (2018). “A physiologically based pharmacokinetic model for pregnant women to predict the pharmacokinetics of drugs metabolized via several enzymatic pathways.” Clinical pharmacokinetics, 57(6), 749–768. doi:10.1007/s40262-017-0594-5.
[Package httk version 2.6.1 Index]