get_wetmore_css {httk} | R Documentation |
Get literature Css (deprecated).
Description
This function is included for backward compatibility. It calls
get_lit_css
which
retrieves a steady-state plasma concentration as a result of
infusion dosing from the Wetmore et al. (2012) and (2013) publications and
other literature.
Usage
get_wetmore_css(
chem.cas = NULL,
chem.name = NULL,
daily.dose = 1,
which.quantile = 0.95,
species = "Human",
clearance.assay.conc = NULL,
output.units = "mg/L",
suppress.messages = FALSE
)
Arguments
chem.cas |
Either the cas number or the chemical name must be specified. |
chem.name |
Either the chemical name or the CAS number must be specified. |
daily.dose |
Total daily dose infused in units of mg/kg BW/day. Defaults to 1 mg/kg/day. |
which.quantile |
Which quantile from the SimCYP Monte Carlo simulation is requested. Can be a vector. |
species |
Species desired (either "Rat" or default "Human"). |
clearance.assay.conc |
Concentration of chemical used in measureing intrinsic clearance data, 1 or 10 uM. |
output.units |
Returned units for function, defaults to mg/L but can also be uM (specify units = "uM"). |
suppress.messages |
Whether or not the output message is suppressed. |
Value
A numeric vector with the literature steady-state plasma concentration (1 mg/kg/day) for the requested quantiles
Author(s)
John Wambaugh
References
Wetmore BA, Wambaugh JF, Ferguson SS, Sochaski MA, Rotroff DM, Freeman K, Clewell III HJ, Dix DJ, Andersen ME, Houck KA, others (2012). “Integration of dosimetry, exposure, and high-throughput screening data in chemical toxicity assessment.” Toxicological Sciences, 125(1), 157–174. doi:10.1093/toxsci/kfr254.
Wetmore BA, Wambaugh JF, Ferguson SS, Li L, Clewell III HJ, Judson RS, Freeman K, Bao W, Sochaski MA, Chu T, others (2013). “Relative impact of incorporating pharmacokinetics on predicting in vivo hazard and mode of action from high-throughput in vitro toxicity assays.” toxicological sciences, 132(2), 327–346. doi:10.1093/toxsci/kft012.
Wetmore BA, Wambaugh JF, Allen B, Ferguson SS, Sochaski MA, Setzer RW, Houck KA, Strope CL, Cantwell K, Judson RS, others (2015). “Incorporating high-throughput exposure predictions with dosimetry-adjusted in vitro bioactivity to inform chemical toxicity testing.” Toxicological Sciences, 148(1), 121–136. doi:10.1093/toxsci/kfv171.
Examples
get_lit_css(chem.cas="34256-82-1")
get_lit_css(chem.cas="34256-82-1",species="Rat",which.quantile=0.5)
get_lit_css(chem.cas="80-05-7", daily.dose = 1,which.quantile = 0.5, output.units = "uM")