chem.invivo.PK.aggregate.data {httk}R Documentation

Parameter Estimates from Wambaugh et al. (2018)

Description

This table includes 1 and 2 compartment fits of plasma concentration vs time data aggregated from chem.invivo.PK.data, performed in Wambaugh et al. 2018. Data includes volume of distribution (Vdist, L/kg), elimination rate (kelim, 1/h), gut absorption rate (kgutabs, 1/h), fraction absorbed (Fabsgut), and steady state concentration (Css, mg/L).

Usage

chem.invivo.PK.aggregate.data

Format

data.frame

Author(s)

John Wambaugh

Source

Wambaugh et al. 2018

References

Wambaugh JF, Hughes MF, Ring CL, MacMillan DK, Ford J, Fennell TR, Black SR, Snyder RW, Sipes NS, Wetmore BA, others (2018). “Evaluating in vitro-in vivo extrapolation of toxicokinetics.” Toxicological Sciences, 163(1), 152–169. doi:10.1093/toxsci/kfy020.


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