auc_2comp {invivoPKfit} | R Documentation |
Analytical AUC for the 2-compartment model
Description
Calculate area under the plasma concentration vs. time curve for the 1-compartment model, using an analytical equation (the integral of the 1-compartment model equation with respect to time).
Usage
auc_2comp(params, time, dose, route, medium = "plasma")
Arguments
params |
A named list of parameter values including the following:
For oral administration (
For oral administration, in lieu of "V1" and "Fgutabs", you may instead provide "Fgutabs_V1", the ratio of Fgutabs to V1 (1/L). This is an alternate parameterization for situations where "Fgutabs" and "V1" are not identifiable separately (i.e. when oral data are available, but IV data are not). If "Fgutabs" and "V1" are provided, then "Fgutabs_V1" will not be used. |
time |
A numeric vector of time values, in hours |
dose |
A numeric vector of doses in mg/kg |
route |
A logical vector: TRUE for single IV bolus dose, FALSE for single oral dose |
medium |
A character string that determines the measured media. Default: "plasma". |
Value
A vector of plasma AUC values, evaluated at each time point in time
.
Author(s)
Caroline Ring, John Wambaugh
See Also
Other built-in model functions:
auc_1comp()
,
auc_1comp_cl()
,
auc_flat()
,
cp_1comp()
,
cp_1comp_cl()
,
cp_2comp()
,
cp_2comp_dt()
,
cp_flat()
,
get_params_1comp()
,
get_params_1comp_cl()
,
get_params_1comp_fup()
,
get_params_2comp()
,
get_params_flat()
,
get_starts_1comp()
,
get_starts_1comp_cl()
,
get_starts_1comp_fup()
,
get_starts_2comp()
,
get_starts_flat()
,
tkstats_2comp()
,
transformed_params_2comp()
Other 2-compartment model functions:
cp_2comp()
,
cp_2comp_dt()
,
get_params_2comp()
,
get_starts_2comp()
,
tkstats_2comp()
,
transformed_params_2comp()
Other model AUC functions:
auc_1comp()
,
auc_1comp_cl()
,
auc_flat()