auc_flat {invivoPKfit}R Documentation

AUC for flat model

Description

Evaluates the area under the concentration-time curve for a "flat" model

Usage

auc_flat(time, params, dose, route, medium)

Arguments

time

A numeric vector of times in hours.

params

A named list of model parameter values. See Details for requirements.

dose

A numeric vector of doses in mg/kg

route

A logical vector: TRUE for single IV bolus dose; FALSE for single oral dose. Not used, but must be present for compatibility with other model functions.

medium

A character vector reflecting the medium in which each resulting concentration is to be calculated: "blood" or "plasma". Default is "plasma". Must be same length as other arguments, or length 1.

Details

# Required parameters

'params' must include the following named items:

Vdist

Apparent volume of central compartment, L/kg BW. Or see below for 'Fgutabs_Vdist'

For oral administration (if any 'route include:

Fgutabs

Oral bioavailability, unitless fraction. Or see below for 'Fgutabs_Vdist'

For oral administration, in lieu of 'Vdist' and 'Fgutabs', you may instead provide 'Fgutabs_Vdist', the ratio of Fgutabs to Vdist (1/L). This is an alternate parameterization for situations where 'Fgutabs' and 'Vdist' are not identifiable separately (i.e., when oral TK data are available, but IV data are not). If 'Fgutabs' and 'Vdist' are provided, they will override any value provided for 'Fgutabs_Vdist'.

If both oral and IV administration are specified (i.e., some 'route and some 'route 'Fgutabs' or 'Fgutabs_Vdist'. (If 'Vdist' and 'Fgutabs_Vdist' are provided, but 'Fgutabs' is not provided, then 'Fgutabs' will be calculated from 'Vdist' and 'Fgutabs_Vdist'.)

If 'any(medium 'Rblood2plasma', the ratio of chemical concentration in whole blood to the chemical concentration in blood plasma.

Value

A vector of plasma concentration values (mg/L) corresponding to time.

Author(s)

Caroline Ring, John Wambaugh, Chris Cook

See Also

Other built-in model functions: auc_1comp(), auc_1comp_cl(), auc_2comp(), cp_1comp(), cp_1comp_cl(), cp_2comp(), cp_2comp_dt(), cp_flat(), get_params_1comp(), get_params_1comp_cl(), get_params_1comp_fup(), get_params_2comp(), get_params_flat(), get_starts_1comp(), get_starts_1comp_cl(), get_starts_1comp_fup(), get_starts_2comp(), get_starts_flat(), tkstats_2comp(), transformed_params_2comp()

Other flat model functions: cp_flat(), get_params_flat(), get_starts_flat()

Other model AUC functions: auc_1comp(), auc_1comp_cl(), auc_2comp()


[Package invivoPKfit version 2.0.1 Index]