tkstats_1comp_cl {invivoPKfit} | R Documentation |
Toxicokinetic statistics for 1-compartment model with specific clearance
Description
Calculate predicted toxicokinetic statistics for a 1-compartment model. This does use the parameters for the 'model_1comp_cl' that are taken from [httk] estimates.
Usage
tkstats_1comp_cl(
pars,
route,
medium,
dose,
time_unit,
conc_unit,
vol_unit,
...
)
Arguments
pars |
A named vector of model parameters (e.g. from [coef.pk()]). |
route |
Character: The route for which to compute TK stats. Currently only "oral" and "iv" are supported. |
medium |
Character: the media (tissue) for which to compute TK stats. Currently only "blood" and "plasma" are supported. |
dose |
Numeric: A dose for which to calculate TK stats. |
time_unit |
Character: the units of time used for the parameters 'par'. For example, if 'par["kelim"]' is in units of 1/weeks, then 'time_unit = "weeks"'. If 'par["kelim"]' is in units of 1/hours, then 'time_unit = "hours"'. This is used to calculate the steady-state plasma/blood concentration for long-term daily dosing of 1 mg/kg/day. |
conc_unit |
Character: The units of concentration. |
vol_unit |
Character: The units of dose. |
... |
Additional arguments not currently in use. |
Details
# Statistics computed
## Total clearance
\textrm{CL}_{tot} = k_{elim} + V_{dist}
## Steady-state plasma concentration for long-term daily dose of 1 mg/kg/day
The dosing interval \tau = \frac{1}{\textrm{day}}
will be converted to
the same units as k_{elim}
.
To convert to steady-state *blood* concentration, multiply by the blood-to-plasma ratio.
### Oral route
C_{ss} = \frac{F_{gutabs} V_{dist}}{k_{elim} \tau}
### Intravenous route
C_{ss} = \frac{1}{24 * \textrm{CL}_{tot}}
## Half-life of elimination
\textrm{Halflife} = \frac{\log(2)}{k_{elim}}
## Time of peak concentration
For oral route:
\frac{\log \left( \frac{k_{gutabs}}{k_{elim}} \right)}{k_{gutabs} -
k_{elim}}
For intravenous route, time of peak concentration is always 0.
## Peak concentration
Evaluate [cp_1comp_cl()] at the time of peak concentration.
## AUC evaluated at infinite time
Evaluate [auc_1comp_cl()] at time = 'Inf'.
## AUC evaluated at the time of the last observation
Evaluate [auc_1comp_cl()] at time = 'tlast'.
Value
A 'data.frame' with two variables: - 'param_name' = 'c("CLtot", "CLtot/Fgutabs", "Css", "halflife", "tmax", "Cmax", "AUC_infinity")' - 'param_value' = The corresponding values for each statistic (which may be NA if that statistic could not be computed).
Author(s)
John Wambaugh, Caroline Ring