cp_flat {invivoPKfit}R Documentation

Flat model

Description

Evaluates a "flat" model for concentration vs. time

Usage

cp_flat(params, time, dose, route, medium = "plasma")

Arguments

params

A named list of parameter values. See Details for requirements.

time

A numeric vector of times, reflecting the time points when concentration is measured after the corresponding single bolus dose. Must be same length as other arguments, or length 1.

dose

A numeric vector of doses, reflecting single bolus doses administered at time 0. Must be same length as other arguments, or length 1.

route

A character vector, reflecting the route of administration of each single bolus dose: ''oral'‘ or '’iv''. Must be same length as 'time' and 'dose', or length 1.

medium

A character vector reflecting the medium in which each resulting concentration is to be calculated: "blood" or "plasma". Default is "plasma". Must be same length as other arguments, or length 1.

Details

This function is used for model comparison: does a 1- or 2-compartment TK model fit the data any better than this naive "flat" model?

# Required parameters

'params' must include the following named items:

Vdist

Apparent volume of central compartment, volume/unit BW. Or see below for 'Fgutabs_Vdist'

For oral administration (if any 'route include:

Fgutabs

Oral bioavailability, unitless fraction. Or see below for 'Fgutabs_Vdist'

For oral administration, in lieu of 'Vdist' and 'Fgutabs', you may instead provide 'Fgutabs_Vdist', the ratio of Fgutabs to Vdist (1/volume). This is an alternate parameterization for situations where 'Fgutabs' and 'Vdist' are not identifiable separately (i.e., when oral TK data are available, but IV data are not). If 'Fgutabs' and 'Vdist' are provided, they will override any value provided for 'Fgutabs_Vdist'.

If both oral and IV administration are specified (i.e., some 'route and some 'route 'Fgutabs' or 'Fgutabs_Vdist'. (If 'Vdist' and 'Fgutabs_Vdist' are provided, but 'Fgutabs' is not provided, then 'Fgutabs' will be calculated from 'Vdist' and 'Fgutabs_Vdist'.)

If 'any(medium 'Rblood2plasma', the ratio of chemical concentration in whole blood to the chemical concentration in blood plasma.

# Flat model equations

## IV administration

\textrm{Conc} = \frac{\textrm{Dose}}{V_{\textrm{dist}}}

## Oral administration

\textrm{Conc} = \frac{F_{\textrm{gutabs}} \textrm{Dose}}{V_{\textrm{dist}}}

Value

A vector of plasma concentration values (mass chemical/volume) corresponding to time.

Author(s)

Caroline Ring, John Wambaugh, Chris Cook

See Also

Other built-in model functions: auc_1comp(), auc_1comp_cl(), auc_2comp(), auc_flat(), cp_1comp(), cp_1comp_cl(), cp_2comp(), cp_2comp_dt(), get_params_1comp(), get_params_1comp_cl(), get_params_1comp_fup(), get_params_2comp(), get_params_flat(), get_starts_1comp(), get_starts_1comp_cl(), get_starts_1comp_fup(), get_starts_2comp(), get_starts_flat(), tkstats_2comp(), transformed_params_2comp()

Other flat model functions: auc_flat(), get_params_flat(), get_starts_flat()

Other model concentration functions: cp_1comp(), cp_1comp_cl(), cp_2comp()


[Package invivoPKfit version 2.0.1 Index]