auc_1comp {invivoPKfit} | R Documentation |
Analytic AUC for 1-compartment model
Description
Calculate area under the plasma concentration vs. time curve for the 1-compartment model, using an analytical equation (the integral of the 1-compartment model equation with respect to time).
Usage
auc_1comp(params, time, dose, route, medium)
Arguments
params |
A named numeric vector of model parameter values. See Details for requirements. |
time |
A numeric vector of times, reflecting the time point when concentration is measured after the corresponding single bolus dose. Must be same length as 'dose' and 'iv.dose', or length 1. |
dose |
A numeric vector of doses, reflecting single bolus doses administered at time 0. Must be same length as 'time' and 'iv.dose', or length 1. |
route |
A character vector, reflecting the route of administration of each single bolus dose: ''oral'‘ or '’iv''. Must be same length as 'time' and 'dose', or length 1. |
medium |
A character vector reflecting the medium in which each resulting concentration is to be calculated: "blood" or "plasma". Default is "plasma". Must be same length as 'time' and 'dose', or length 1. |
Details
# Required parameters
'params' must include the following named items:
- kelim
Elimination rate, 1/time.
- Vdist
Apparent volume of central compartment, volume/unit BW. Or see below for 'Fgutabs_Vdist'
For oral administration (if any 'route include:
- Fgutabs
Oral bioavailability, unitless fraction. Or see below for 'Fgutabs_Vdist'
- kgutabs
Rate of absorption from gut, 1/time.
For oral administration, in lieu of 'Vdist' and 'Fgutabs', you may instead provide 'Fgutabs_Vdist', the ratio of Fgutabs to Vdist (1/volume). This is an alternate parameterization for situations where 'Fgutabs' and 'Vdist' are not identifiable separately (i.e., when oral TK data are available, but IV data are not). If 'Fgutabs' and 'Vdist' are provided, they will override any value provided for 'Fgutabs_Vdist'.
If both oral and IV administration are specified (i.e., some 'route and some 'route 'Fgutabs' or 'Fgutabs_Vdist'. (If 'Vdist' and 'Fgutabs_Vdist' are provided, but 'Fgutabs' is not provided, then 'Fgutabs' will be calculated from 'Vdist' and 'Fgutabs_Vdist'.)
If 'any(medium 'Rblood2plasma', the ratio of chemical concentration in whole blood to the chemical concentration in blood plasma.
Value
A vector of plasma AUC values (concentration*time) corresponding to 'time'.
Author(s)
Caroline Ring, John Wambaugh
See Also
Other built-in model functions:
auc_1comp_cl()
,
auc_2comp()
,
auc_flat()
,
cp_1comp()
,
cp_1comp_cl()
,
cp_2comp()
,
cp_2comp_dt()
,
cp_flat()
,
get_params_1comp()
,
get_params_1comp_cl()
,
get_params_1comp_fup()
,
get_params_2comp()
,
get_params_flat()
,
get_starts_1comp()
,
get_starts_1comp_cl()
,
get_starts_1comp_fup()
,
get_starts_2comp()
,
get_starts_flat()
,
tkstats_2comp()
,
transformed_params_2comp()
Other 1-compartment model functions:
auc_1comp_cl()
,
cp_1comp()
,
cp_1comp_cl()
,
get_params_1comp()
,
get_params_1comp_cl()
,
get_params_1comp_fup()
,
get_starts_1comp()
,
get_starts_1comp_cl()
,
get_starts_1comp_fup()
Other model AUC functions:
auc_1comp_cl()
,
auc_2comp()
,
auc_flat()