addIndirectLin {nlmixr2lib} | R Documentation |
Add linear indirect response model
Description
Add linear indirect response model
Usage
addIndirectLin(
ui,
stim = c("in", "out"),
inhib = c("in", "out"),
ek = "Ek",
ik = "Ik",
kin = "kin",
kout = "kout",
cc = "Cc",
R = "R",
effect = "effect"
)
Arguments
ui |
rxode2 model |
stim |
what type of stimulation indirect response model: - 'in': stimulation of input - 'out': stimulation of output |
inhib |
what type of inhibition indirect response model: - 'in': inhibition of input - 'out': inhibition of output |
ek |
simulation linear constant |
ik |
inhibition linear constant |
kin |
this is the kin parameter name |
kout |
this is the kout parameter name |
cc |
the concentration value |
R |
drug response compartment |
effect |
the effect variable that will be modeled |
Value
model with linear indirect effect added
Note that while linear indirect effects are not common, it allows an easier hook to produce other standard effect curves like Emax/Imax, Hill, etc.
Author(s)
Matthew L. Fidler
See Also
Other Indirect response:
addIndirect()
,
convertKinR0()
Examples
readModelDb("PK_2cmt_no_depot") |> addIndirectLin(stim="in")
readModelDb("PK_2cmt_no_depot") |> addIndirectLin(stim="out")
readModelDb("PK_2cmt_no_depot") |> addIndirectLin(inhib="in")
readModelDb("PK_2cmt_no_depot") |> addIndirectLin(inhib="out")
[Package nlmixr2lib version 0.3.0 Index]