penalised.weights.delta {MendelianRandomization} | R Documentation |
Calculates p-values for penalization of weights with second-order weights
Description
Internal function for calculating penalized weights in conjunction with r.weights
with weights
equal to "delta"
.
These weights are used in either the mr_ivw
or mr_egger
functions when penalized = TRUE
, or in the mr_median
function when method = "penalized"
.
Usage
penalised.weights.delta(.Bx, .Bxse, .By, .Byse, .psi)
Arguments
.Bx |
Beta-coefficient for genetic association with the risk factor. |
.Bxse |
Standard error of genetic association with the risk factor. |
.By |
Beta-coefficient for genetic association with the outcome. |
.Byse |
Standard error of genetic association with the outcome. |
.psi |
The correlation between the genetic associations with the exposure and the association with the outcome for each variant resulting from sample overlap. |
Details
None.
Value
P-values corresponding to heterogeneity test for each genetic variant in turn (based on a chi-squared-1 distribution).
Examples
penalised.weights.delta(ldlc, ldlcse, chdlodds, chdloddsse, 0)