OneCompIVbolus {PKPDsim}R Documentation

ADVAN-style equations

Description

Adapted from Abuhelwa et al. JPET 2015

Usage

OneCompIVbolus(d)

Arguments

d

data, a NONMEM style data frame for 1 subject with columns for TIME, AMT, MDV, DV, CL, V

Details

Functions for calculating drug amount in each compartments of the common pharmacokinetic models (1,2,3 compartment IV bolus, IV infusion, and first-order absorption models)

Definitions:

Value

Returns a dataframe with populated columns for A1, and DV

References

Abuhelwa, A. Y., Foster, D. J. R., Upton, R. N. (2015) ADVAN-style analytical solutions for common pharmacokinetic models. J Pharmacol Toxicol Methods 73:42-8. DOI: 10.1016/j.vascn.2015.03.004


[Package PKPDsim version 1.4.1 Index]