sampsize_1stage_2arm {frequentistSSD} | R Documentation |
Calculate the sample size for each arm
Description
Provide the required sample size (per arm) based on the one-stage selection design given the type I error rate and power. Details see the reference paper
Usage
sampsize_1stage_2arm(kappa, alpha, beta, m0, m1, ta, tf, delta)
Arguments
kappa |
the shape parameter of weibull distribution |
alpha |
type I error rate |
beta |
type II error rate |
m0 |
the median survival time of historical control with respect to both arm A and B |
m1 |
the median survival time of arm A |
ta |
the accrual duration |
tf |
the follow-up duration |
delta |
the hazard ratio of arm B to arm A |
Value
sampsize_1stage_2arm()
returns required sample size for each arm
Author(s)
Chia-Wei Hsu, Haitao Pan, Jianrong Wu
References
Jianrong Wu, Haitao Pan, Chia-Wei Hsu (2021). "Two-Stage Screened Selection Designs for Randomized Phase II Trials with Time-to-Event Endpoints." Submitted
Examples
sampsize_1stage_2arm(kappa = 1, alpha = 0.05, beta = 0.1, m0 = 1,
m1 = 2.5, delta = 0.65, ta = 24, tf = 9)
[Package frequentistSSD version 0.1.1 Index]