dat.furukawa2003 {metadat} | R Documentation |
Studies on Low Dosage Tricyclic Antidepressants for the Treatment of Depression
Description
Results on depression severity from 17 studies comparing low dosage tricyclic antidepressants (TCA) and placebo for the treatment of depression.
Usage
dat.furukawa2003
Format
The data frame contains the following columns:
author | character | First author with information on dosage in parentheses |
Ne | integer | number of patients in low TCA group |
Me | numeric | depression severity (low TCA) |
Se | numeric | standard deviation (low TCA) |
Nc | integer | number of patients in placebo group |
Mc | numeric | depression severity (placebo) |
Sc | numeric | standard deviation (placebo) |
Details
Furukawa et al. (2003) carried out a systematic review comparing low dosage tricyclic antidepressants (TCA) with placebo for the treatment of depression. They reported the effect on presence/absence of depression and on depression severity at various time points. Here we focus on depression severity at four weeks. Most studies used some version of the Hamilton Depression Rating Scale, however, some studies used the Montgomery-Asberg Depression Rating Scale. Accordingly, it is not possible to pool the estimated effects directly.
This data set is used as an example in Schwarzer et al. (2015).
Concepts
standardized mean differences
Author(s)
Guido Schwarzer, guido.schwarzer@uniklinik-freiburg.de, https://github.com/guido-s/
Source
Furukawa, T. A., McGuire, H., & Barbui, C. (2003). Low dosage tricyclic antidepressants for depression. Cochrane Database of Systematic Reviews, 3, CD003197. https://doi.org/10.1002/14651858.CD003197
References
Schwarzer, G., Carpenter, J. R., & Rücker, G. (2015). Meta-analysis with R. Cham, Switzerland: Springer.
Examples
### Show first five studies
head(dat.furukawa2003, 5)
## Not run:
### Load meta package
suppressPackageStartupMessages(library("meta"))
### Use RevMan5 settings
oldset <- settings.meta("RevMan5", digits = 2)
### Conduct random effects meta-analysis with Hedges' g as effect measure
mc2 <- metacont(Ne, Me, Se, Nc, Mc, Sc, common = FALSE,
data = dat.furukawa2003, sm = "SMD")
mc2
### Use previous settings
settings.meta(oldset)
## End(Not run)